A new study is about to start at UCLA Jonsson Comprehensive Cancer Center, looking at the use of cryoablation before surgery for the treatment of pleural mesothelioma.

What is cryoablation?

Cryoablation is also known as cryosurgery or cryotherapy. It uses liquid nitrogen or argon gas to freeze tumours. The extreme cold destroys the cancer cells.

Currently, cryoablation has only been used on kidney, liver and prostate cancers but it has been found to be effective in killing tumour cells. This will be the first study to look at cryoablation as a treatment for pleural mesothelioma.

Recruitment starting at end of July

The study expects to start recruiting participants at the end of July. It is hoped there will be at least 20 patients involved. They will be made up of pleural mesothelioma patients who are suitable for surgery and the treatment will be administered when they undergo the standard pleural biopsy.

Patients will receive 30 minutes of cryoablation at the time of their biopsy and during subsequent surgery, samples will be taken from areas that have been treated with cryoablation as well as areas non treated. This will allow researchers to evaluate the cryo-immune stimulation in mesothelioma.

No expected results

Dr Neema Jamshidi, the lead researcher does not know what kind of results to expect, “There are no promises that it will help a patient or not at this point. We know that when there are recurrent lesions, cryoablation can kill the tissue. We want to know if there are additional benefits.”

The results of the study are expected early next year.

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Source:

ClinicalTrials.gov. (2020, June 12). Cryoablation for the Promotion of Local Tumor Infiltration in Patients with Mesothelioma. Retrieved from: https://clinicaltrials.gov/ct2/show/NCT04429204

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