Inhibitor drugs could be a new treatment for mesothelioma patients.

What is mesothelioma?

Mesothelioma is an incurable cancer. It affects the linings of the body’s organs and is caused by asbestos exposure. Sadly, no cure for the cancer is currently available. However, treatments continue to advance and research is progressing. This allows some people to survive with mesothelioma for longer.

How can inhibitor drugs help?

Recent research by a team at the Netherlands Cancer Institute and University College London has looked at drugs that stop a particular cell pathway.

Fibroblast growth factor receptor (FGFR) is a signalling pathway important for tissue regeneration and the growth of new blood vessels. Research now shows that FGFR may also affect the development of some cancers, including peritoneal and pleural mesothelioma.

Researchers tested a panel of nearly 900 cancer cell lines for genetic alterations. Tests showed a link between high sensitivity to FGFR inhibition and genetic mutation, known as BAP1 loss.

Researcher, Josine Quispel-Janssen, MD, said; “None of the lines harboured genomic alterations of FGFR family members but rather BAP1 protein loss was associated with enhanced sensitivity to FGFR inhibition”.

The study appears to have found a link between a genetic alteration in the BAP1 gene and FGFR sensitivity in mice with mesothelioma. This has also been seen in human cell samples.

This research is a positive step for mesothelioma patients. We hope that further progress can be made into mesothelioma treatment in the future.

How can we help?

If you require assistance in pursuing an asbestos compensation claim for mesothelioma or other asbestos disease then please contact us today. You can do so by calling our freephone number 0800 038 6767. Alternatively, head over to the ‘Contact Us’ page, complete the form and we will be in touch.

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